New research suggests that individuals who stop using popular slimming jabs like semaglutide or tirzepatide may regain lost weight far faster than those who end conventional lifestyle programs.
Findings released in a major health publication points out that while obese individuals frequently drop substantial amounts of their total mass while using the jabs, the weight returns at an estimated rate of 0.8 kg per month once they quit.
"Individuals purchasing these treatments should be informed of the risk of quick weight regain when the treatment concludes," cautioned researcher Dr. Susan Jebb.
That rate of regain means a reversion to starting weight in about a year and a half.
Weighing Therapies
The research, which reviewed dozens of trials involving over 9,000 of patients, contrasted the results of these new drugs with conventional dieting.
Researchers emphasize that individuals who shed pounds through dieting usually see a slower weight regain—perhaps 100 grams monthly—once they finish.
The Reason for the Quick Rebound
Doctors propose the way of the drugs accounts for the amplified regain.
The injections imitate a natural hormone called GLP-1, which moderates appetite.
"Artificially providing GLP-1 concentrations several times higher than the body's typical production may cause the system to generate a reduced amount of its own natural hormone, and may also reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication results in appetite is unsuppressed, making binge eating far more likely."
An Ongoing Disease?
Health authorities suggest the injections for people with obesity-related health risks, alongside recommended lifestyle changes.
Many experts contend that, given the significant potential of weight regain, the therapy is often ongoing.
This view is reinforced by drug manufacturers, who say that the results "highlight the long-term nature of excess weight," akin to managing diseases like high blood pressure.
Patient Experiences
People who have stopped the medication report a sudden resurgence of cravings.
"It felt as if a switch that goes on and you're instantly ravenous," recalled an individual.
This difficulty is compounded if users have not established lasting lifestyle or habit modifications during therapy.
Growing Adoption
Figures show that millions of people in the UK have tried these injections in the past year, with demand continuing to grow.
- Use is greater among females than men.
- The 40s and 50s demographic shows the highest level of interest.
- A large proportion access the drugs through private prescriptions rather than public health services.
Ultimately, clinicians caution that while these medications are potent agents for weight loss, they are not a permanent cure and lasting health benefits likely depends on combined behavioural changes.
